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KMID : 0368820090480050394
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Journal of the Korean Neuropsychiatr Association
2009 Volume.48 No. 5 p.394 ~ p.397
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A Case of Paraneoplastic Stiff-Person Syndrome Presenting Multiple Somatic Symptoms
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Myung Woo-Jae
Kang Eun-Ho
Yu Bum-Hee
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Abstract
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Stiff-person syndrome (SPS) is an unusual autoimmune neurological disease. We report a woman who developed stiff-person syndrome associated with thymoma. A 42-year-old woman visited a general hospital complaining of progressive rigidity in her neck and both lower legs. She also had other symptoms including whole body pruritus, dysphargia, dysarthria, diplopia, and a visual hallucination-like symptom. Emotional distress preceded her symptoms. After a extensive neurologic workup, she was transferred from the neurologic ward to the psychiatric ward under the impression of conversion or somatoform disorder. During her psychiatric admission, we found a prolonged involuntary MUAP discharge on her electromyograph, and positive anti-GAD and anti-GQ1b antibodies. In addition, a chest CT scan revealed a thymic epithelial tumor. We report a case of stiff-person syndrome presenting multiple unexplained somatic symptoms, which was initially diagnosed as a conversion or somatoform disorder.
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KEYWORD
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Stiff-person syndrome, Thymoma, Conversion disorder, Somatoform disorder
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